diff --git a/chrome/test/chromedriver/test/run_py_tests.py b/chrome/test/chromedriver/test/run_py_tests.py
index be69b5523b2fc6..dea5963eb0ce8f 100755
--- a/chrome/test/chromedriver/test/run_py_tests.py
+++ b/chrome/test/chromedriver/test/run_py_tests.py
@@ -89,6 +89,8 @@
     'ChromeLogPathCapabilityTest.testChromeLogPath',
     # https://bugs.chromium.org/p/chromium/issues/detail?id=946704
     'ChromeDownloadDirTest.testFileDownloadWithClick',
+    # https://bugs.chromium.org/p/chromium/issues/detail?id=1025981
+    'ChromeDriverSiteIsolation.testCanClickOOPIF',
     'ChromeDriverTest.testBackNavigationAfterClickElement',
     'ChromeDriverTest.testCanClickInIframes',
     'ChromeDriverTest.testClickElementAfterNavigation',