diff --git a/Modules/_testcapimodule.c b/Modules/_testcapimodule.c
index 03a4acbc798475..11015df011a5d3 100644
--- a/Modules/_testcapimodule.c
+++ b/Modules/_testcapimodule.c
@@ -3070,7 +3070,7 @@ slot_tp_del(PyObject *self)
     /* Execute __del__ method, if any. */
     del = _PyObject_LookupSpecial(self, &PyId___tp_del__);
     if (del != NULL) {
-        res = PyEval_CallObject(del, NULL);
+        res = _PyObject_CallNoArg(del);
         if (res == NULL)
             PyErr_WriteUnraisable(del);
         else
diff --git a/Modules/_threadmodule.c b/Modules/_threadmodule.c
index 8be9306d6a13f8..bf25a19eb25076 100644
--- a/Modules/_threadmodule.c
+++ b/Modules/_threadmodule.c
@@ -994,8 +994,7 @@ t_bootstrap(void *boot_raw)
     _PyThreadState_Init(tstate);
     PyEval_AcquireThread(tstate);
     nb_threads++;
-    res = PyEval_CallObjectWithKeywords(
-        boot->func, boot->args, boot->keyw);
+    res = PyObject_Call(boot->func, boot->args, boot->keyw);
     if (res == NULL) {
         if (PyErr_ExceptionMatches(PyExc_SystemExit))
             PyErr_Clear();
diff --git a/Modules/_tkinter.c b/Modules/_tkinter.c
index f69a4dfed9bd2b..1abc0e225e99f9 100644
--- a/Modules/_tkinter.c
+++ b/Modules/_tkinter.c
@@ -2417,7 +2417,7 @@ PythonCmd(ClientData clientData, Tcl_Interp *interp, int argc, const char *argv[
         }
         PyTuple_SET_ITEM(arg, i, s);
     }
-    res = PyEval_CallObject(func, arg);
+    res = PyObject_Call(func, arg, NULL);
     Py_DECREF(arg);
 
     if (res == NULL)
@@ -2661,16 +2661,13 @@ static void
 FileHandler(ClientData clientData, int mask)
 {
     FileHandler_ClientData *data = (FileHandler_ClientData *)clientData;
-    PyObject *func, *file, *arg, *res;
+    PyObject *func, *file, *res;
 
     ENTER_PYTHON
     func = data->func;
     file = data->file;
 
-    arg = Py_BuildValue("(Oi)", file, (long) mask);
-    res = PyEval_CallObject(func, arg);
-    Py_DECREF(arg);
-
+    res = PyObject_CallFunction(func, "Oi", file, mask);
     if (res == NULL) {
         errorInCmd = 1;
         PyErr_Fetch(&excInCmd, &valInCmd, &trbInCmd);
@@ -2840,7 +2837,7 @@ TimerHandler(ClientData clientData)
 
     ENTER_PYTHON
 
-    res  = PyEval_CallObject(func, NULL);
+    res = _PyObject_CallNoArg(func);
     Py_DECREF(func);
     Py_DECREF(v); /* See Tktt_New() */
 
diff --git a/Objects/abstract.c b/Objects/abstract.c
index 589d9e8fd9b067..4a75b92e1d0895 100644
--- a/Objects/abstract.c
+++ b/Objects/abstract.c
@@ -1329,7 +1329,7 @@ PyNumber_Long(PyObject *o)
     }
     trunc_func = _PyObject_LookupSpecial(o, &PyId___trunc__);
     if (trunc_func) {
-        result = PyEval_CallObject(trunc_func, NULL);
+        result = _PyObject_CallNoArg(trunc_func);
         Py_DECREF(trunc_func);
         if (result == NULL || PyLong_CheckExact(result)) {
             return result;
diff --git a/Objects/fileobject.c b/Objects/fileobject.c
index 3c3d46da512f54..0f71944d526ec8 100644
--- a/Objects/fileobject.c
+++ b/Objects/fileobject.c
@@ -49,6 +49,7 @@ PyFile_FromFd(int fd, const char *name, const char *mode, int buffering, const c
 PyObject *
 PyFile_GetLine(PyObject *f, int n)
 {
+    _Py_IDENTIFIER(readline);
     PyObject *result;
 
     if (f == NULL) {
@@ -56,32 +57,18 @@ PyFile_GetLine(PyObject *f, int n)
         return NULL;
     }
 
-    {
-        PyObject *reader;
-        PyObject *args;
-        _Py_IDENTIFIER(readline);
-
-        reader = _PyObject_GetAttrId(f, &PyId_readline);
-        if (reader == NULL)
-            return NULL;
-        if (n <= 0)
-            args = PyTuple_New(0);
-        else
-            args = Py_BuildValue("(i)", n);
-        if (args == NULL) {
-            Py_DECREF(reader);
-            return NULL;
-        }
-        result = PyEval_CallObject(reader, args);
-        Py_DECREF(reader);
-        Py_DECREF(args);
-        if (result != NULL && !PyBytes_Check(result) &&
-            !PyUnicode_Check(result)) {
-            Py_DECREF(result);
-            result = NULL;
-            PyErr_SetString(PyExc_TypeError,
-                       "object.readline() returned non-string");
-        }
+    if (n <= 0) {
+        result = _PyObject_CallMethodIdObjArgs(f, &PyId_readline, NULL);
+    }
+    else {
+        result = _PyObject_CallMethodId(f, &PyId_readline, "i", n);
+    }
+    if (result != NULL && !PyBytes_Check(result) &&
+        !PyUnicode_Check(result)) {
+        Py_DECREF(result);
+        result = NULL;
+        PyErr_SetString(PyExc_TypeError,
+                   "object.readline() returned non-string");
     }
 
     if (n < 0 && result != NULL && PyBytes_Check(result)) {
@@ -197,7 +184,7 @@ PyObject_AsFileDescriptor(PyObject *o)
     }
     else if ((meth = _PyObject_GetAttrId(o, &PyId_fileno)) != NULL)
     {
-        PyObject *fno = PyEval_CallObject(meth, NULL);
+        PyObject *fno = _PyObject_CallNoArg(meth);
         Py_DECREF(meth);
         if (fno == NULL)
             return -1;
diff --git a/Objects/typeobject.c b/Objects/typeobject.c
index f18a79526b27b9..18b67c83258dcb 100644
--- a/Objects/typeobject.c
+++ b/Objects/typeobject.c
@@ -4348,7 +4348,7 @@ _common_reduce(PyObject *self, int proto)
     if (!copyreg)
         return NULL;
 
-    res = PyEval_CallMethod(copyreg, "_reduce_ex", "(Oi)", self, proto);
+    res = PyObject_CallMethod(copyreg, "_reduce_ex", "Oi", self, proto);
     Py_DECREF(copyreg);
 
     return res;
diff --git a/Objects/weakrefobject.c b/Objects/weakrefobject.c
index ab6b23525552b8..d12db9185d8611 100644
--- a/Objects/weakrefobject.c
+++ b/Objects/weakrefobject.c
@@ -461,7 +461,7 @@ proxy_checkref(PyWeakReference *proxy)
 
 WRAP_BINARY(proxy_getattr, PyObject_GetAttr)
 WRAP_UNARY(proxy_str, PyObject_Str)
-WRAP_TERNARY(proxy_call, PyEval_CallObjectWithKeywords)
+WRAP_TERNARY(proxy_call, PyObject_Call)
 
 static PyObject *
 proxy_repr(PyWeakReference *proxy)