Can scKTLD be used in bulk Hi-C data?

[dangdachang]

Hello, scKTLD seems to be a powerful tool to find TAD-like domains and reconstruct the contact matrix of single-cell Hi-C data. I wonder whether scKTLD can be used in traditional bulk Hi-C data to find TAD, or in bulk Hi-C data with insufficient sequencing reads. If yes, do the parameters need to be adjusted?

I look forward to hearing from you, thank you!

[lhqxinghun]

Yes，scKTLD can be used for bulk Hi-C data with insufficient sequencing reads. You can use the optimal parameters reported in our paper, and the parameters can be further optimized for your own dataset for better performance.

[dangdachang]

Thanks for your reply. I can use scKTLD now.